Prevention of Acute Vomiting (minimum of 2 mg/kg) To maximize therapeutic potential of CERENIA, the underlying cause of vomiting should be identified and addressed in dogs receiving CERENIA. Drug compatibility should be monitored in patients requiring adjunctive therapy.ĬERENIA causes dose related decreases in appetite and body weight (see ANIMAL SAFETY). The influence of concomitant drugs that may inhibit the metabolism of CERENIA has not been evaluated. Commonly used protein bound drugs include NSAIDs, cardiac, anticonvulsant, and behavioral medications. The concomitant use of CERENIA with other protein bound drugs has not been studied in dogs. Use with caution with other medications that are highly protein bound. Use with caution in dogs with hepatic dysfunction because CERENIA is metabolized by CYP3A enzymes (see Pharmacokinetics). The safe use of CERENIA has not been evaluated in dogs with gastrointestinal obstruction, or dogs that have ingested toxins. The safe use of CERENIA Tablets has not been evaluated in dogs used for breeding, or in pregnant or lactating bitches. In puppies 16 weeks and older, bone marrow hypocellularity was not observed (see ANIMAL SAFETY). In puppies younger than 11 weeks of age, histological evidence of bone marrow hypocellularity was observed at higher frequency and greater severity in puppies treated with CERENIA compared to control puppies. In case of accidental eye exposure, flush with water for 15 minutes and seek medical attention. Wash hands with soap and water after administering drug. Repeated or prolonged exposure may lead to skin sensitization. Topical exposure may elicit localized allergic skin reactions in some individuals. In case of accidental ingestion, seek medical advice. Prevention of Vomiting Due to Motion Sickness in Dogs 4 months of age and older:ĭispense whole or half tablets in strengths that most closely result in an 8 mg/kg dose once daily for up to 2 consecutive days:ĬERENIA injectable solution should not be used interchangeably with CERENIA tablets for the prevention of vomiting due to motion sickness (8mg/kg). (See package insert for CERENIA injectable solution.) Thereafter, for the prevention of acute vomiting, CERENIA Tablets at a dose of 2 mg/kg once daily may be used interchangeably with CERENIA Injectable Solution for up to 5 days.įor Prevention of Vomiting Due to Motion Sickness in dogs 4 months and olderįor Prevention of Vomiting due to motion sickness in dogs 4 months of age and older: Administer CERENIA Tablets orally at a minimum dose of 8 mg/kg (3.6 mg/lb) body weight once daily for up to 2 consecutive days (see WARNINGS and Animal Safety).Īdminister CERENIA Tablets a minimum of two hours prior to travel with a small amount of food to mitigate vomiting associated with administration of the dose on an empty stomach however, refrain from feeding a full meal prior to travel. In dogs that are actively vomiting, to ensure that the full initial dose is administered, CERENIA Injectable Solution is recommended at a dose of 1 mg/kg once daily. Interchangeable use with CERENIA Injectable Solution for Prevention of Acute Vomiting:
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